Para la úlcera del pie diabético, Heberprot-P es un fármaco desarrollado por el “Centro de Ingeniería Genética y Biotecnología (CIGB) en 2007 en Cuba.
La diabetes ya no se considera mortal; no obstante, la diabetes y las complicaciones derivadas de ella, cuando no están controladas, siguen siendo la sexta causa principal de muerte, con una tasa de mortalidad superior a la de algunos cánceres como el cáncer de próstata, cáncer de mama y el cáncer de colon. Una de las complicaciones más comunes y graves de la diabetes es la úlcera del pie diabético, que afecta aproximadamente al 15% – 20% de las personas con diabetes y con frecuencia conduce a la amputación del miembro inferior (alrededor del 84% de las amputaciones de las extremidades inferiores se deben a esta condición).
La úlcera del pie diabético ocurre cuando una úlcera o una herida se desarrolla en una zona de las piernas inferiores o los pies que no cicatriza o es difícil de tratar, lo que conduce a la exposición del tejido subyacente y lo vuelve susceptible a infecciones..
Síntomas y clasificación
No es inusual que las personas con diabetes tengan úlceras del pie diabético durante algún tiempo sin ser conscientes de su aparición. Algunos de los síntomas a los que debe prestar atención incluyen:
- Uñas de los pies gruesas y amarillas
- Mal olor del pie
- Piel tensa, hinchazón, enrojecimiento u otros signos de infección
- Dificultad para caminar
- Dolor muscular o cramps que se producen con la actividad y desaparecen con el reposo
- decoloración del pie
- Úlceras o llagas en el pie
Según el Sistema de clasificación de Wagner, las úlceras del pie diabético se clasifican entre 0 y 5:
- 0 – el pie es normal pero está en riesgo de desarrollar úlceras del pie diabético
- 1 – ligera ulceración sin infección
- 2 – úlceras con tendones y articulaciones expuestos
- 3 – ulceración extensa con infección
- 4 – gangrena de dedo(s) del pie o del antepié
- 5 – gangrena del retropié o del mediopié
CAUSAS DE LA ÚLCERA DEL PIE DIABÉTICO
Uno de los principales factores contribuyentes para desarrollar la úlcera del pie diabético es neuropatía periférica.(daño nervioso) que surge debido a un aumento, aunque sea leve, del nivel de glucemia. Debido al daño nervioso y a la pérdida de sensaciones y de la capacidad de sentir dolor, los daños en el pie, incluso por causas tan simples como la presión del calzado o un pequeño corte, pasan desapercibidos y sin protección, lo que provoca empeoramiento de la pérdida de piel, ampollas y la posibilidad de una infección grave que puede progresar en cuestión de días.
Estrechamiento de las arterias (enfermedad arterial periférica) debido a la diabetes reduce el suministro de sangre a los pies y es otra complicación diabética que contribuye al desarrollo de las úlceras del pie diabético. Una lesión en una zona con mala circulación sanguínea tarda más en cicatrizar y es más difícil de tratar, lo que la hace propensa a desarrollar úlceras o gangrena (descomposición de las células debido a la falta de flujo sanguíneo).
FACTOR DE CRECIMIENTO EPIDÉRMICO (EGF) Y DIABETES
Numerosos estudios han demostrado que los pacientes diabéticos presentan una disminución en las concentraciones de factores de crecimiento, principalmente factor de crecimiento epidérmico (EGF). Naturalmente presente en el organismo, el EGF estimula y promueve el crecimiento y la regeneración celular al unirse a sus receptores: los receptores del factor de crecimiento epidérmico (EGFR). El factor de crecimiento epidérmico actúa como agente de cicatrización al acelerar la recuperación de las heridas al desencadenar la síntesis de colágeno, elastina y ácido hialurónico.
De ello se deduce que las personas diabéticas con una cantidad reducida de EGF tienen una mayor probabilidad de presentar cicatrización deficiente de las heridas, hasta extremos que pueden desarrollar complicaciones graves que requieran amputación del miembro inferior.
HEBERPROT-P
Heberprot-P es un producto cubano innovador con EGF como ingrediente principal, administrado a pacientes que padecen úlceras que no cicatrizan y no responden a otros tratamientos convencionales. Sigue siendo la única alternativa a la amputación para las úlceras del pie diabético. Alrededor de 160,000 pacientes con úlcera del pie diabético han sido tratados con Heberprot-P con éxito, reduciendo el riesgo de amputación en un 77%.
El uso de Heberprot-P para las úlceras del pie diabético tiene una influencia significativa en la calidad de vida global del paciente, ya que no solo acelera el proceso de cicatrización, reduce el número de cirugías necesarias para la eliminación de tejido dañado y disminuye el riesgo de desarrollar complicaciones como infecciones y gangrena, sino que también reduce el riesgo de amputación y los costos de hospitalización.
Heberprot-P se administra por vía parenteral y está libre de conservantes. Ha demostrado una relación beneficio–riesgo favorable y se ha demostrado que se tolera bien con efectos secundarios leves a moderados, siendo el dolor y la sensación de ardor en el sitio de administración los más frecuentes.
Según la Organización Mundial de la Salud (OMS), Heberprot-P fue registrado en Cuba en 2006 y ahora está registrado en 15 otros países, lo que ha permitido tratar a más de 100,000 pacientes; las solicitudes para su registro están en revisión en otros países, incluidos Brasil, China, la Federación de Rusia, Sudáfrica y los estados árabes del Golfo Pérsico.
Heberprot-P ha ganado la Medalla de Oro de la Organización Mundial de la Propiedad Intelectual (OMPI) y el Premio al Mejor Joven Inventor en la Exposición Internacional de Invenciones en Ginebra, Suiza.
55 comments
Atung Achi
March 31, 2019 at 5:52 am
I enjoyed reading this information about diabetes treatment. How can purchase this drug from Nigeria? I am suffering from type 2
Jing
March 18, 2020 at 4:19 pm
Hi I’m from China and my dad is suffering the foot ulcer now. I think his type 3 and it been almost two months. The wounds are healing very slow pace. I don’t know whether I could buy in China, probably not, if is there has any channels for me to buy the drug? Thanks very much.
CHMT Team
March 27, 2020 at 10:58 pm
Dear Jing,
We are forwarding your inquiry to our admin department in order for them to supply with full program details and the cost.
Best regards,
CHMT Team
Sushila
August 8, 2024 at 2:42 pm
I enjoy reading information from Toronto very informative
NWAZIRI Sixtus
April 27, 2019 at 8:50 am
Please how can I get this drug in Lagos Nigeria my junior sister is a diabetic patient and she has an ulcer on left hand
CHMT
May 22, 2019 at 10:30 pm
Dear NWAZIRI,
Your request has been forwarded to our admin department in order for them to reach out to you.
Best regards,
CHMT team
Claudia Ocville
June 6, 2019 at 6:12 am
Please how can I get this drug for my dad .I live at New york
CHMT
June 18, 2019 at 3:48 pm
Dear Claudia,
Your inquiry has been forwarded to our admin department in order for them to follow up with you.
Best regards,
CHMT Team
Natasha
June 21, 2019 at 1:18 am
How can I get this drug , my uncle is in serious need of this ASAP. Please help
CHMT Team
July 19, 2019 at 6:52 pm
Dear Natasha,
Your inquiry has been forwarded to our admin department in order for them to follow up with you.
Best regards,
CHMT Team
Eren
November 11, 2024 at 8:17 pm
Bu ilaçı bir hemşire yaraya kullanabilir mi yada Türkiye de hangi doktor yapıyor ?
Acil bir dönüş sağlarsanız
CHMT Client Care
December 6, 2024 at 2:02 am
Dear Eren,
Your inquiry had been forwarded to our admin department in order for them to reach out to you with full details of the possible treatment options, the costs, and the steps you are required to complete in order for the admin team to be able to forward your complete medical dossier to the Cuban Medical Authorities (CMA) for evaluation and determination of suitability.
Best regards
mohammed (Last name is withheld for privacy purposes)
August 12, 2019 at 9:30 am
Please how can I get this drug for my dad .I live at india
CHMT team
September 28, 2019 at 8:13 pm
Dear Mohammed,
Your inquiry has been forwarded to our admin department in order for them to follow up with you.
Best regards,
CHMT Team
Nikola (Last name is withheld for privacy purposes)
September 25, 2019 at 8:48 pm
Hi my name is Nikola and my father has problem with diabetic ulcers and we need this medication how can we get this medication to Serbia?
Please let me know.
Thank you.
CHMT team
September 28, 2019 at 7:28 pm
Dear Nikola,
Your inquiry has been forwarded to our admin department in order for them to follow up with you.
Best regards,
CHMT Team
David
October 12, 2019 at 6:33 am
Cure for hepatitis b
CHMT team
October 24, 2019 at 7:48 pm
Dear David,
We are forwarding your inquiry to our admin department in order for them to follow up with you regarding possible treatment of this condition.
Best regards,
CHMT team
Diane
November 1, 2019 at 7:06 am
How can i get this medication?
CHMT team
November 18, 2019 at 10:36 pm
Dear Diane,
We are forwarding your inquiry to our admin department in order for them to supply with full program details and the cost.
Best regards,
CHMT Team
Heidi (Last name withheld for privacy purposes)
February 10, 2020 at 1:54 am
How can I get treatment with this drug for my mother, she has an ulcer on her large toe and it is dry gangrene. Not infected yet.
CHMT team
February 27, 2020 at 4:53 pm
Dear Heidi,
We are forwarding your inquiry to our admin department in order for them to supply with full program details and the cost.
Best regards,
CHMT Team
Queen (Last name withheld for privacy purposes)
February 26, 2020 at 9:33 pm
How can it e purchased inUS?
Dango
March 23, 2020 at 12:01 pm
I have suffering from diabetics past two years. Till I am not take medicine. But tring to control. B.Fasting 260. After fasting 400. Medicine are available? I am from India
David (Last name withheld for privacy purposes)
April 29, 2020 at 1:21 am
My name is David Hou and I am from Solomon Islands, my wife is having diabetic and I want to medicine for her. How can I bring it to Solomon Islands? Thanks so much.
David (Last name withheld for privacy purposes)
April 29, 2020 at 4:11 am
Any possibility of getting this drug to Solomon Islands, I’m a diabetic person for 2 years now. And I don’t know what to do.
Thanks so much.
CHMT Team
May 4, 2020 at 3:13 pm
Dear David,
We are forwarding your inquiry to our admin department in order for them to supply with full program details and the cost.
Best regards,
CHMT Team
Etratia (Last name withheld for privacy purposes)
May 7, 2020 at 9:16 am
How can I get the treatment for my uncle it has already been infected and it sometimes bleeds and his foot is swollen and he already lost a bone from one of his toes
CHMT Team
May 7, 2020 at 2:56 pm
Dear Etratia,
We are forwarding your inquiry to our admin department in order for them to supply with full program details and the cost.
Best regards,
CHMT Team
CHMT Team
May 7, 2020 at 2:59 pm
Dear Yadira,
We are forwarding your inquiry to our admin department in order for them to supply with full program details and the cost.
Best regards,
CHMT Team
Alexander (Last name withheld for privacy reasons)
June 13, 2020 at 12:52 am
Is there way to buy this in US?
Thank you
CHMT Team
August 27, 2020 at 12:06 am
Dear Alexander,
This is a prescribed injection which requires the presence of the patient in the Republic of Cuba in order to undergo through and in-depth evaluation and testing. furthermore, in the vast majority of the cases, and prior to applying this injection, the patient will be required to undergo toilet surgery/ surgeries to remove the dead tissues prior to applying the injections into the open area. We are forwarding your inquiry to our admin department in order for them to reach out to you with full details of the treatment/ surgical program, the cost, and the steps the patient is required to follow in order for the admin team to be able to forward a complete medical dossier to the Cuban Medical Authorities (CMA) for evaluation and determination of suitability.
Regards,
CHMT team
CHMT Client Care
April 6, 2023 at 7:52 pm
Dear Alexander,
Kindly be aware, Heberprot-P is a prescribed medicine. In order for the patient to qualify for treatment of diabetic foot ulcer, the patient must travel to Cuba in order to undergo thorough evaluation and testing prior to the Heberprot-P injections being administered at the hands of highly qualified specialists. Furthermore, and in all likelihood, your mother would need to undergo what is known as “toilet surgeries” (multiple) prior to the injection being applied to the exposed areas.
Yours,
CHMT Client care
Dorin
June 15, 2020 at 5:38 pm
Hello,
I am interested in treatment for foot ulcer.
I think is rated 2 – ulcers with exposed tendons and joints.
Thank you
CHMT Team
August 26, 2020 at 11:59 pm
Dear Dorin,
Your inquiry has been forwarded to our admin department in order for them to reach out to you with full details of the possible surgical program, the cost, and the steps you are required to follow in order for the admin team to be able to forward your complete medical dossier to the Cuban Medical Authorities (CMA) for evaluation and determination of suitability.
Best regards,
CHMT team
Raquel (Last name withheld for privacy reasons)
June 21, 2020 at 10:14 pm
Hola, mi padre esta en el hospital con una infeccion en el pie por un pequeño corte, pero ahora no tiene circulacion en los dedos del pie y tiene un dedo negro y los otros dedos estan comenzando a quedar negro, tiene riesgo de amputacion , el es diabetico y siempre esta alta el azucar , y sufre de tencion alta tambien.. me gustaria un consejo…gracias..
CHMT Team
August 26, 2020 at 11:58 pm
Dear Raquel,
Su consulta ha sido enviada a nuestro departamento de administración para que se comuniquen con usted con todos los detalles del posible programa quirúrgico, el costo y los pasos que debe seguir para que el equipo de administración pueda enviar su expediente médico completo a las Autoridades Médicas Cubanas (CMA) para evaluación y determinación de idoneidad.
Atentamente,
CHMT Team
CHMT Client Care
April 6, 2023 at 7:48 pm
Querida Raquel,
Su consulta ha sido enviada a CHMT LA, que es nuestra compañía hermana que está a cargo de los pacientes latinoamericanos.
Atentamente,
CHMT Client Care
Donaldo
October 12, 2020 at 2:21 am
I live in the USA, hoe can i get my hands on the treatment for my grandmother who has a really bad ulcer on her foot?
CHMT Client Care
April 6, 2023 at 7:31 pm
Dear Donaldo,
Kindly be aware, Heberprot-P is a prescribed medicine. In order for the patient to qualify for treatment of diabetic foot ulcer, the patient must travel to Cuba in order to undergo thorough evaluation and testing prior to the Heberprot-P injections being administered at the hands of highly qualified specialists. Furthermore, and in all likelihood, your mother would need to undergo what is known as “toilet surgeries” (multiple) prior to the injection being applied to the exposed areas.
Yours,
CHMT Client care
zhangkuifeng
October 29, 2020 at 2:32 am
price list; instructions
CHMT Client Care
April 6, 2023 at 7:25 pm
Dear zhangkuifeng,
Kindly elaborate on what you mean by “price list/ instructions”
Yours,
CHMT Client Care
Amrich
May 17, 2022 at 4:03 am
How can I get this medication for my brother. He has diabetic type 1. We is from Bosnia. Please give me more information how to get this med?
CHMT Client Care
June 10, 2022 at 10:12 pm
Dear Amrich,
Your inquiry had been forwarded to our admin department.
Best regards
Monica (Last name omitted for privacy purposes)
June 6, 2022 at 7:05 pm
My father suffers from diabetic ulcers
We would very much like to take part in study or purchase drug
CHMT Client Care
June 10, 2022 at 9:50 pm
Dear Monica,
Your inquiry had been forwarded to our admin department.
Best regards
Tatyana (last name withheld for privacy protection)
September 28, 2022 at 1:47 am
Hello,
My aunt suffers from diabetic ulcers, I live in Florida. Where and how can we purchase this medication?
CHMT Client care
March 17, 2023 at 11:22 pm
Dear Tatyana,
Kindly be aware, and in order to receive treatment for your aunts’ diabetic ulcers’ condition utilizing Heberprot-P, your aunt’s presence in the Republic of Cuba is a must. This is in order for the patient to undergo thorough evaluation and testing prior to the medicine being prescribed. Any claim of otherwise is most definitely by fraudulent entities trying to take advantage of patients’ vulnerability and the success of Melagenina Plus.
Your inquiry had been forwarded to our admin department in order for them to reach out to you with full details of the treatment/ surgical program, the costs, and the steps you are required to complete in order for the admin team to be able to forward your brother’s complete medical dossier to the Cuban Medical Authorities for evaluation and determination of treatment suitability.
Best regards
Aleksandra (last name withheld for privacy protection)
February 2, 2023 at 10:01 am
I have a friend who needs this treatment. We are in Australia. He lives in Sydney, and he is currently in Westmead hospital. Do you know if Heberprot-P is available in Australia and where can we saurce it from? Kind regards Aleksandra
CHMT Client care
March 17, 2023 at 8:30 pm
Dear Aleksandra,
Your inquiry had been forwarded to our admin department in order for them to reach out to you with full details of the treatment/ surgical program, the costs, and the steps you are required to complete in order for the admin team to be able to forward your friend’s complete medical dossier to the Cuban Medical Authorities for evaluation and determination of treatment suitability.
Best regards
Mingzhe
May 12, 2024 at 4:32 am
Hello, I am currently in Ontario Canada, I want to buy this product for my friend’s father living in China, Please tell me how to get this medicine thank you so much.
Petra
September 14, 2025 at 12:03 pm
Hello, we are in Canada and our father is severely suffering with a foot ulcer for a few years now. I would categorize his ulcer as a type 3. The wounds are not healing and we are desperately seeking alternative options. If there may be any channels for us to buy the drug, we would appreciate your assistance. Thanks very much.
CHMT Client Care
September 22, 2025 at 4:55 pm
Dear Petra,
Your inquiry had been forwarded to our admin department in order for them to reach out to you with full details of the possible treatment options, the costs, and the steps you are required to complete in order for the admin team to be able to forward your complete medical dossier to the Cuban Medical Authorities (CMA) for evaluation and determination of suitability.
Best regards
Camila (apellido retenido por motivos de protección de la privacidad) ccs.cl
December 27, 2025 at 6:43 pm
Por favor, sou do Brasil. Fortaleza Ceará. Queria saber de algum médico que faça tratamento com essa medicação pro meu pai. É urgente! Por favor me ajuda
CHMT Client Care
January 12, 2026 at 11:25 pm
Estimada Camila:
Su consulta ha sido remitida a nuestro departamento administrativo para que puedan comunicarse con usted y proporcionarle todos los detalles sobre las posibles opciones de tratamiento, los costos y los pasos que debe completar para que el equipo administrativo pueda remitir su expediente médico completo a las Autoridades Médicas Cubanas (CMA) para su evaluación y determinación de idoneidad.
Atentamente